ISSN 2398-2985      

Uterine neoplasia

6guinea pig

Synonym(s): Uterine tumor, Leiomyoma, Leiomyosarcoma


Introduction

  • Cause: unknown, but can experimentally be induced with exposure to estradiol, diethylstilbesterol or testosterone (leiomyomas). There may be a link between estrogen-secreting ovarian cysts and uterine neoplasia.
  • Signs: abdominal enlargement (may be mistaken for pregnancy), may have hemorrhagic vaginal discharge, abdominal pain, lethargy, anorexia.
  • Diagnosis: cytology of vaginal discharge including Gram’s stain to rule out pyometra. Radiography, ultrasonography, histopathology, CBC.
  • Treatment: ovariohysterectomy.
  • Prognosis: good if there has been no metastasis.

Pathogenesis

Etiology

  • Unknown, but can experimentally be induced with exposure to estradiol, diethylstilbesterol or testosterone.
  • Several tumor types have been documented:
    • Most are benign.
    • Leiomyoma.
    • Fibroma.
  • Rarely malignant tumors have been documented:
    • Leiomyosarcoma.
    • Myxosarcoma.

Predisposing factors

General

  • Intact female, sexually mature.

Pathophysiology

  • Although it is considered that 50% of uterine neoplasia is malignant, metastasis seems rare.
  • Ovarian and uterine neoplasia can be induced experimentally by administration of estradiol, diethylstilbestrol or testosterone.
  • There may be a link between estrogen-secreting ovarian cysts Cystic ovarian disease and uterine neoplasia.

Timecourse

  • Likely slow, but as there is usually no outward clinical sign of the tumor starting, it is unknown how long it may take to develop.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Schuetzenhofer G, Goericke-Pesch S & Wehrend A (2011) Effects of deslorelin implants on ovarian cysts in guinea pigs. Schweiz Arch Tierheilkd 153 (9), 416-417 PubMed.
  • Greenacre C B (2004) Spontaneous tumors of small mammals. Vet Clin Exot Anim 7 (3), 627-651 PubMed.
  • Silva E G, Tornos C, Deavers M et al (1998) Induction of epithelial neoplasms in the ovaries of guinea pigs by estrogenic stimulation. Gynecol Oncol 71 (2), 240-246 PubMed.
  • Silva E G, Tornos C, Fritsche H A Jr et al (1997) The induction of benign epithelial neoplasms of the ovaries of guinea pigs by testosterone stimulation: a potential animal model. Mod Pathol 10 (9), 879-883 PubMed.
  • Porter K B, Tsibris J C, Nicosia S V et al (1995) Estrogen-induced guinea pig model for uterine leiomyomas: do the ovaries protect? Biol Reprod 52 (4), 824-932 PubMed.

Other sources of information

  • Hawkins M G & Bishop C R (2012) Disease Problems of Guinea Pigs. In: Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. 3rd edn. Eds: Quesenberry K E & Carpenter J W. Elsevier. pp 295-310.
  • Percy D H & Barthold S W (2007) Guinea Pigs. In: Pathology of Laboratory Rodents and Rabbits. 3rd edn. Eds: Percy D H & Barthold S W. Blackwell Publishing. pp 217-251.

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