ISSN 2398-2985      

Splenomegaly

6guinea pig

Synonym(s): Enlargement of the spleen


Introduction

  • Cause: a type C retrovirus has been associated.
  • Signs: rough hair coat, anemia (pale mucus membranes), hepatomegaly, lymph node enlargement.
  • Diagnosis: blood smears; histopathology of spleen.
  • Treatment: chemotherapy may be attempted.
  • Prognosis: poor.

Pathogenesis

Etiology

  • Type C retrovirus; reported as an endogenous retrovirus of the lymphopoietic system.

Pathophysiology

  • Type C retrovirus infecting the lymphopoietic system, causing a B-cell lymphocytic leukemia.
  • White blood cell counts may be elevated 25,000 to 500,000 mm3. Spleen, lymph nodes, and liver affected and enlarged.

Timecourse

  • Rapid, with death often within 2-5 weeks of onset.

Epidemiology

  • Has been reported to be more transplantable than transmissible; pet guinea pigs are likely to have been infected young, as many are relatively isolated since purchase.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Hawkins M G & Bishop C R (2012) Disease Problems of Guinea Pigs. In: Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. 3rd edn. Eds: Quesenberry K E & Carpenter J W. Elsevier. pp 295-310.
  • Harkness J E, Turner P V, Vandewoude S & Wheler C L (2010) Harkness and Wagner’s Biology and Medicine of Rabbits and Rodents. 5th edn. Wiley-Blackwell. pp 343.
  • Orr H (2009) Rodents: Neoplastic and Endocrine Disease. In: BSAVA Manual of Rodents and Ferrets. Eds: Keeble E & Meredith A. British Small Animal Veterinary Association. pp 181-192.

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