ISSN 2398-2985      

Pulmonary neoplasia

6guinea pig
Contributor(s):

Synonym(s): Pulmonary adenoma, Bronchogenic papillary adenoma


Introduction

  • Cause: unknown.
  • Signs: may be asymptomatic early and just found incidentally.
  • Diagnosis: thoracic radiography. At necropsy, histopathology of lesions.
  • Treatment: asymptomatic as there is no treatment for the neoplasia itself.
  • Prognosis: grave.

Pathogenesis

Etiology

  • Unknown.
  • One of the most common tumors found in guinea pigs. In one study represented 35% of all neoplasias.
  • Benign pulmonary adenomas.
  • Bronchogenic and alveologenic adenocarcinomas have also been documented.

Predisposing factors

General

  • Aging.

Pathophysiology

  • Pulmonary adenomas are considered to arise from bronchogenic cells.
  • Radiographic changes as well as some histopathologic changes are similar to those produced by some infectious agents.
  • It has been theorized that there may be an initial hyperplastic and adenomatous changes in the airways and alveoli. Hence findings may not represent true primary pulmonary tumors. This work was performed in a laboratory setting, and also included exposure to inhaled carcinogens and asbestos which may have impacted on findings.

Timecourse

  • Slow-growing, but exact timecourse has not been reported.

Epidemiology

  • Unknown if infectious respiratory disease initiates this, as the guinea pig may not be showing active bacterial respiratory infection at the time the tumors are discovered. This infection may be secondary to neoplasia due to poor mucocilliary action.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Greenacre C B (2004) Spontaneous tumors of small mammals. Vet Clin Exot Anim 7 (3), 627-651 PubMed.

Other sources of information

  • Hawkins M G & Bishop C R (2012) Disease Problems of Guinea Pigs. In: Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. 3rd edn. Eds: Quesenberry K E & Carpenter J W. Elsevier. pp 295-310.
  • Percy D H & Barthold S W (2007) Guinea Pigs. In: Pathology of Laboratory Rodents and Rabbits. 3rd edn. Eds: Percy D H & Barthold S W. Blackwell Publishing. pp 217-251.
  • Schaeffer D O & Donnelly T M (1997) Disease Problems of Guinea Pigs and Chinchillas. In: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery. Eds: Hillyer E V & Quesenberry K E. W B Saunders, USA. pp 260-282.

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