ISSN 2398-2985      

Lymphosarcoma

6guinea pig

Synonym(s): LSA, Lymphoma


Introduction

  • Cause: unknown. In the literature it is often reported in combination with leukemia.
  • Signs: anorexia, lethargy, poor grooming/hair coat, peripheral lymphadenopathy, hepatomegaly, splenomegaly, mediastinal masses.
  • Diagnosis: lymph node biopsy/fine needle aspirate with cytology, histology; radiography, ultrasonography; necropsy with histopathology.
  • Treatment: theoretically lymphosarcoma protocols as used in other species could be attempted, but no successful treatment has been reported.
  • Prognosis: grave. Highly malignant and rapidly progresses.

Pathogenesis

Etiology

  • Lymphosarcoma has sometimes been linked with Cavian leukemia Leukemia which has been linked to a type-C retrovirus.
  • Lymphosarcoma has also been found without B-cell leukemia.

Pathophysiology

  • With the leukemia Leukemia, the type C retrovirus alters the B-cell function and reproduction.
  • Lymphosarcoma: neoplastic lymphocytes proliferate in lymph nodes, liver, spleen predominantly.

Timecourse

  • A course of 2-5 weeks is reported with leukemia.

Epidemiology

  • The type-C retrovirus is considered endogenous, so spread between guinea pigs may not be horizontal but vertical.
  • Unknown for the true lymphosarcoma where no leukemia is associated with it and there is uncertainty whether a retrovirus is involved.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Hawkins M G & Bishop C R (2012) Disease Problems of Guinea Pigs. In: Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. 3rd edn. Eds: Quesenberry K E & Carpenter J W. Elsevier. pp 295-310.
  • Orr H (2009) Rodents: neoplastic and endocrine disease.  In: BSAVA Manual of Rodents and Ferrets. Eds: Keeble E & Meredith A. British Small Animal Veterinary Association. pp 181-192.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code