ISSN 2398-2985      

Lymphocytic choriomeningitis

6guinea pig

Synonym(s): LCM


Introduction

  • Cause: lymphocytic choriomeningitis virus, an Arenavirus, RNA virus.
  • Signs: wasting, anorexia, diarrhea. May show ataxia, paresis/paralysis, seizures.
  • Diagnosis: serology is available. On necropsy, lymphocytic infiltrates in the meninges, choroid plexi, ependyma, liver, adrenals, lungs, as well as lesions throughout the small intestine. Viral antigen can be identified in tissues. Electron microscopy of feces will show viral particles.
  • Treamtent: none.
  • Prognosis: may recover as the disease is considered to have low morbidity and mortality.

Pathogenesis

Etiology

  • LCMV an Arenavirus.
  • In some literature it is characterized as 'coronavirus-like'.

Predisposing factors

General

  • Disease outbreaks have been recorded in young guinea pigs that have recently arrived at a facility.

Pathophysiology

  • Relatively rare in guinea pigs.
  • An acute to subacute necrotizing enteritis of primarily the distal ileum. Large amount of mucoid material present throughout the gastrointestinal tract.
  • Virus infiltrates the meninges, choroid plexi and ependymal. It also infiltrates the liver, adrenals, and lungs.

Timecourse

  • Acute to subacute for signs of enteritis Enteritis.

Epidemiology

  • Infection is through inhalation, ingestion, or contact through intact skin.
  • Considered to be low morbidity and mortality.
  • Considered to be introduced into domestic guinea pigs through wild rodents.
  • Can be transmitted to other species, including humans.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Prevention

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed Papers

Other sources of information

  • Antinoff N (2011) Paresis and Paralysis. In: Blackwell's Five-Minute Veterinary Consult: Small Mammal. Ed: Oglesbee B L. Wiley-Blackwell. pp 303-306.
  • Antinoff N (2011) Seizures. In: Blackwell's Five-Minute Veterinary Consult: Small Mammal. Ed: Oglesbee B L. Wiley-Blackwell. pp 326-328.
  • Harkness J E, Turner P V, Vandewoude S & Wheler C L (2010) Harkness and Wagner’s Biology and Medicine of Rabbits and Rodents. 5th edn. Wiley-Blackwell. pp 322-324.
  • Percy D H & Barthold S W (2007) Guinea Pigs. In: Pathology of Laboratory Rodents and Rabbits. 3rd edn. Eds: Percy D H & Barthold S W. Blackwell Publishing. pp 217-251.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code