ISSN 2398-2985      

Fibrous osteodystrophy

6guinea pig

Synonym(s): Satin disease


Introduction

  • Cause: suspected genetic cause in Satin breeds or those with some Satin genetic backgrounds.
  • Signs: anorexia, difficulty eating, lethargy, difficulty walking or unwillingness to move, pathologic fractures.
  • Diagnosis: radiography, dietary history, plasma total and ionized calcium concentrations, serum 25-hydroxyvitamin D, differentiate from Vitamin C deficiency.
  • Treatment: diet correction, calcium gluconate IM, followed by oral calcium glubionate daily, supplemental Vitamin D3 and sunlight, pain management, assisted feeding, parenteral fluids as needed.
  • Prognosis: guarded, particularly if Satin genetic backgrounds. 

Pathogenesis

Etiology

  • Suspected genetic factors with the Satin haircoat genes (Satin is a breed where the hair shafts are tubular and reflect light, giving the coat a sheen).
  • With dietary causes such as low mineral levels, imbalanced Ca:P.
  • Primary or secondary hyperparathyroidism.
  • May have vitamin D deficiency.
  • May have calcium malabsorption.
  • May have some type of calcium metabolism disturbance.

Predisposing factors

General

  • Dietary imbalances of Ca:P
  • Dietary vitamin D deficiency.

Specific

  • Satin breed or mixed Satin breed.

Pathophysiology

  • Increased osteoclastic resorption of bone with replacement by fibrous tissue.
  • Plasma total and ionized calcium may be low.
  • Vitamin D levels may be low.

Timecourse

  • Gradual onset.

Epidemiology

  • Reported in Satin breed in Europe, United States.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

Other sources of information

  • Hawkins M G & Bishop C R (2012) Disease Problems of Guinea Pigs. In: Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. 3rd edn. Eds: Quesenberry K E & Carpenter J W. Elsevier. pp 295-310.

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