ISSN 2398-2985      

Cryptococcosis

6guinea pig

Synonym(s): Cryptococcosus neoformans


Introduction

  • Cause: Cryptococcus neoformans, a fungus.
  • Signs: ulcerative dermatitis. As an experimental model of Cryptococcal meningitis, one would expect neurologic signs. Although respiratory and systemic forms of cryptococcosis are reported in other species, spontaneous disease other than ulcerative dermatitis have not been found in guinea pigs.
  • Diagnosis: for the ulcerative dermatitis, skin scraping or biopsy, culture and identification of the organism. As an animal model, diagnostic work was necropsy confirmation after experimental innoculation.
  • Treatment: itraconazole effective for experimental meningeal cryptococcosis.
  • Prognosis: cannot be determined from the literature. Likely good for spontaneous cryptococcosis of the skin.

Pathogenesis

Etiology

  • Cryptococcus neoformans, an environmental fungus.
  • One reference mentions a skin disease. Most of the literature is of the use of the guinea pig as an animal model for Cryptococcal meningitis and neurologic disease in humans.
  • The reference for the ulcerative dermatitis is likely for spontaneous infection with the organism.
  • It has been injected intravenously into guinea pigs to produce meningitis as they are the animal model.

Predisposing factors

General

  • Not specified.
  • Any guinea pig that is vitamin C deficient Vitamin C deficiency may have immunosuppression.

Pathophysiology

  • For spontaneous ulcerative dermatitis, Cryptococcus neoformans invades the cutaneous tissues.

Epidemiology

  • In a pet with spontaneous skin infection, it is possible that other animals and humans in the household could be infected, as the organism is an environmental contaminant.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Van Cusem J (1993) Therapy of experimental meningeal and disseminated cryptococcosis. Mycoses 36 (11-12), 357-367 PubMed.

Other sources of information

  • Longley L (2009) Rodents: Dermatoses. In: BSAVA Manual of Rodents and Ferrets. Eds: Keeble E & Meredith A. British Small Animal Veterinary Association. pp 107-122.

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