ISSN 2398-2985      

Adenovirus infection

6guinea pig

Synonym(s): Adenoviral pneumonia, GpAV, GAV


Introduction

  • Cause: infection with adenovirus resulting in necrotizing bronchitis, bronchiolitis, pneumonitis and pneumonia.  
  • Signs: may be asymptomatic. Respiratory disease with dyspnea, coughing. Death.
  • Diagnosis: rule out other causes of pneumonia, coughing. Radiography, bacterial culture/sensitivity from exudates, complete blood count, serum biochemistries, serology is commercially available, PCR has been used in research laboratories, transtracheal wash or bronchoalveolar lavage.
  • Treatment: none specifically.
  • Prognosis: grave in clinically affected animals.

Pathogenesis

Etiology

  • Infection with adenovirus Adenovirus: a DNA virus.

Predisposing factors

General

  • Reports from laboratory colonies suggest manipulations may impair the immune response.

Pathophysiology

  • Adenovirus affects the lower respiratory tract.
  • Experimental intranasal inoculation of newborn guinea pigs using homogenates prepared from lung of spontaneous disease has caused typical lesions in the lungs.

Timecourse

  • Incubation period is 5-10 days.

Epidemiology

  • Low morbidity but high mortality (approaching 100%) in clinically affected animals.
  • Spread via aerosols and direct contact.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Pring-Akerblom P, Blazek K, Schramlova et al (1997) Polymerase chain reaction for detection of guinea pig adenovirus. J Vet Diagn Invest 9 (3), 232-236 PubMed.

Organisation(s)

  • Hawkins M G & Bishop C R (2012) Disease Problems of Guinea Pigs. In: Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. 3rd edn. Eds: Quesenberry K E & Carpenter J W. Elsevier. pp 295-310.
  • Charles River Laboratories (2011) Guinea Pig Adenovirus (GpAV, GAV). Technical Sheet Website: www.criver.com. Last Accessed 27th February 2017.
  • Percy D H & Barthold S W (2007) Guinea Pigs. In: Pathology of Laboratory Rodents and Rabbits. 3rd edn. Eds: Percy D H & Barthold S W. Blackwell Publishing. pp 217-251.

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