ISSN 2398-2985      

Ranitidine

4ferrets

Synonym(s): Ranitidine HCl, Zantac


Introduction

Name

  • Ranitidine.
  • Usually available and used as the hydrochloride salt, ranitidine hydrochloride.
  • Ranitidine bismuth citrate also used in human medicine.

Class of drug

  • Histamine (H2) receptor antagonist.

Description

Chemical name

  • (E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydrochloride

Molecular formula

  • C13H22N4O3S.
  • C13H23ClN4O3S (ranitidine HCl).

Molecular weight

  • 314.40.
  • 350.86 (ranitidine HCl).

Physical properties

  • White to pale yellow granular substance.
  • Water soluble.
  • Slightly bitter taste.
  • Sulfur-like odor.

Storage requirements

  • Tablets: store in tight, light-resistant containers at room temperature.
  • Injectable: store at room temperature and protected from light.
  • A slight darkening of the injectable solution does not affect the potency of the drug.

Uses

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Indications

  • Used to treat gastric and duodenal ulcers, including NSAID-induced ulceration.
  • Used to treat Helicobacter-induced gastritis and ulcers, in combination with other drugs.
  • Used prophylactically to prevent stress ulcers.
  • Adjunct therapy for reversing metabolic alkalosis.
  • Immunomodulation.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Fewer drug interactions than cimetidine.
  • Antacids, digoxin, ketoconazole or metoclopramide: ranitidine may reduce their absorption or effect.
  • Sucralfate: may reduce the absorption of ranitidine.

with diagnostic tests

  • Little information available.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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