ISSN 2398-2985      

Metoclopramide

4ferrets

Introduction

Name

  • Metoclopramide.

Class of drug

  • Gastrointestinal prokinetic agent.
  • Upper gastrointestinal tract stimulant.

Description

Chemical name

  • 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide.

Molecular formula

  • C14H22CIN3O2.

Molecular weight

  • 299.79.

Physical properties

  • Odorless, white, crystalline powder.
  • One gram is soluble in 0.7 mL of water and 3 mL of alcohol.

Storage requirements

  • Store in light-resistant containers at room temperature.

Uses

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Indications

  • Acts as an upper gastrointestinal stimulant with antiemetic properties.
  • Prevention of emesis in cases of chemotherapy.
  • Prevention of gastroesophageal reflux and enhancer of gastroesophageal motility in cases of megaesophagus.
  • Its use to prevent vomiting in gastritis is questionable.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Antimuscarinic drugs, eg atropine, and narcotic analgesics
  • The activity of metoclopropamide may be inhibited.
Narcotics, sedatives or tranquilizers
  • The central nervous system (CNS) effects of metoclopramide may be enhanced.
Tetracyclines, cyclosporine
  • Metoclopramide increase the rate and extent of GI absorption.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Quesenberry K E, Carpenter J W (2004) Formulary. In: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery. 2nd edn. pp 436-444.

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 195.
  • Plumb D (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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