ISSN 2398-2985      

Buprenorphine

4ferrets

Introduction

Name

  • Buprenorphine.

Class of drug

  • Partial agonist or agonist-antagonist.

Description

Chemical name

  • (2-5R,6R,7R,14S)-9alpha-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylbutan-2-ol.

Molecular formula

  • C29H41NO4.

Molecular weight

  • 467.64.

Physical properties

  • White crystalline powder. 
  • Soluble in water (up to 17 mg/mL) and alcohol (up to 42 mg/mL).

Storage requirements

  • Store at room temperature and protected from light.
  • Do not freeze.

Uses

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Indications

  • May be mixed with acepromazine or midazolam to produce neuroleptanalgesia for minor procedures or pre-operative medication.
  • Sedative and euphoric effects less marked than those produced by morphine.
  • Preferred opiod for mild to moderate pain.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Opioid analgesics
  • Do not use in conjunction with these as it is a partial agonist and will antagonize the effects of full agonists (morphine, pethidine).
  • May potentiate sedative and ventilatory depressant effects of other CNS depressants, including local anesthetics.
  • Can be used to reverse sedative effects of fentanyl/fluanisone while maintaining analgesia.
  • Azolic antifungals and eyrthromycin: increase plasma buprenorphine.
  • Anticonvulsants and rifampin: decrease plasma buprenorphine.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, UK. pp 338.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • Morrisey J K & Carpenter J W (2012) Formulary. In: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery. 3rd edn. Eds: Quesenberry K E & Carpenter J W. Elsevier. pp 566-575.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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