ISSN 2398-2977      

CSF: protein

pequis

Overview

  • Total protein and protein fractions vary with type of central nervous system (CNS) pathology and etiology.
  • Normally low, ie much less than plasma protein, increased protein in the cerebrospinal fluid (CSF) may be due to altered permeability of the blood brain barrier (mainly albumin) and/or local immunoglobulin production.
  • Most proteins are derived from plasma by diffusion, some immunoglobulins are from intrathecal biosynthesis.
  • Specific quantities of IgG and albumin are usually determined.

Sampling

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Tests

Methodologies

  • Microprotein method: accurate at low protein concentrations.
  • Precipitation and dye-binding methods.
  • Urinary protein re-agent strips for detection of grossly elevated total protein.
  • Protein electrophoresis   →   relative proportions, eg albumin versus globulin, helps identify source of protein: via increased permeability of blood-brain barrier or from local source (production by meninges).

Validity

Sensitivity

  • Microprotein method, sensitive to 0.1 g/l.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Johnson P J & Constantinescu G M (2000) Collection of cerebrospinal fluid in horses. Equine Vet Educ 12, 7-12.
  • Johnson P J & Constantinescu G M (2000) Analysis of cerebrospinal fluid in horses. Equine Vet Educ 12, 13-17.
  • Miller M M, Sweeney C R, Russell G E et al (1999) Effects of blood contamination of cerebrospinal fluid on Western blot analysis for detection against sarcocystis neurona and on albumin quotient and IgG index in horses. JAVMA 215, 67-71 PubMed.

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