ISSN 2398-2977      

Sarmazenil

pequis

Introduction

Name

  • Sarmazenil.

Class of drug

  • Partial inverse agonist of benzodiazepine receptors.

Description

Chemical name

  • Ethyl 7-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-[1,5-a][1,4]benzodiazeine-3-carboxylate.

Molecular formula

  • C15H14ClN3O3.

Molecular weight

  • 319.7.

Uses

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Indications

  • Benzodiazepine reversal agent.
  • Has been used to reverse the effects of climazolam   Climazolam  in horses.
  • Used in single case report as a reversal agent in a foal with moxidectin overdose (a GABAa receptor agonist).

Sarmazenil is not licensed for use in the UK. It is available in Switzerland for veterinary use only.

Administration

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Precautions

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Interactions

with other drugs

  • None known.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Müller J-M V et al (2005) The use of sarmazenil in the treatment of a moxidectin intoxication in a foal. J Vet Intern Med 19 (3), 348-349 PubMed.
  • Bettschart-Wolfensberger R et al (1996) Physiologic effects of anesthesia induced and maintained by intravenous administration of a climazolam-ketamine combination in ponies premedicated with acepromazine and xylazine. Am J Vet Res 57 (10), 1472-1477 PubMed.

Other sources of information

  • Muir W W (2009) Anxiolytics, Nonopioid Sedative-Analgesics and Opioid Analgesics. In: Equine Anesthesia: Monitoring and Emergency Therapy. 2nd edn. Eds: W W Muir & J A E Hubbell. Saunders Elsevier, UK. pp 185-209.

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