ISSN 2398-2977      

Rocuronium

pequis

Synonym(s): Esmeron


Introduction

Name

  • Rocuronium bromide.

Class of drug

  • Non-depolarizing muscle relaxant.
  • Animo steroid.

Description

Chemical name

  • 1-[17ß-(acetyloxy)-3alpha-hydroxy-2ß-(4-morpholinyl)-5-androstan-16ß-yl]-1-(2-propenyl) pyrrolidinium bromide.

Molecular formula

  • C32H53N2O4+.

Molecular weight

  • 529.774 g.

Physical properties

  • Clear, colorless solution.
  • Excipients:
    • Sodium acetate.
    • Sodium chloride.
    • Acetic acid.
    • Water.
    • Contains no preservatives.

Storage requirements

  • Store between 2-8°C; protect from light.
  • Can be stored <30°C for up to 12 weeks; once stored outside the refrigerator it must not be returned to the refrigerator.

Uses

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Indications

  • Part of a balanced anesthetic technique.
  • Paralysis of skeletal muscles during general anesthesia to facilitate:
    • Intraocular surgery.
    • Fracture reduction.
    • Deep abdominal surgery.
    • Thoracotomy.
    • Facilitation of effective intermittent positive pressure ventilation.

Muscle relaxants have no sedative, anesthetic or analgesic properties, therefore adequate analgesia and anesthesia are required in a paralyzed patient.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

with diagnostic tests

  • NMBAs eliminate the most obvious signs of an inadequate depth of anesthesia.
  • Palpebral reflex, eye movement and gross purposeful movement cannot be relied upon to detect a light plane of general anesthesia during paralysis.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Auer U & Moens Y (2011) Neuromuscular blockade with rocuronium bromide for ophthalmic surgery in horse. Vet Ophthal 14, 244-247 PubMed.
  • Mosing M, Auer U, Bardell D et al (2010) Reversal of profound rocuronium block monitored in three muscle groups with sugammadex in ponies. Brit J Anaes 105, 480-486 PubMed.
  • Auer U, Uray C & Mosing M (2007) Observations on the muscle relaxant rocuronium bromide in the horse a dose response study. Vet Anaes Analg 34, 75-81 PubMed.
  • Clutton E (2007) Surgical muscle relaxation and neuromuscular blockade. In Prac 29, 574-583.

Other sources of information

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