ISSN 2398-2977      

Penicillin G

pequis
Contributor(s):

Sally Anne Argyle

Synonym(s): Benzylpenicillin, procaine penicillin G, penicillin G procaine


Introduction

Name

  • Penicillin G.

Class of drug

Description

Chemical name

  • [2S-(2-alpha,5-alpha,6-beta)]-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Molecular formula

  • C16H18N2O4S.

Physical properties

  • Sterile powder.
  • Sterile, aqueous suspension.

Storage requirements

  • Powder:
    • <25°C.
  • Suspension:
    • Between 2-8°C.
    • Do not store in freezer.
    • Protect from light.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

  • Penicillin-sensitive infections.
  • Primary Gram-positive organisms but not beta-lactamase producing.
  • A drug of choice for the management of streptococcal infections in the horse.
  • Strangles   Strangles (Streptococcus equi infection)  caused byStreptococcus equi.

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

  • Synergistic with the beta-lactam antibacterials.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Widmer A, Kummer M, Wehrli Eser M & Furst A (2009) Comparison of the clinical efficacy of cefquinome with the combination of penicillin G and gentamicin in equine patients. Equine Vet Educ 21 (8), 430-435.
  • Murchie T A et al (2006) Continuous monitoring of penicillin G and gentamicin in allantoic fluid of pregnant pony mares byin vitromicrodialysis. Equine Vet J 38 (6), 520-525.
  • Gustafsson A et al (2004) Study of fecal shedding of Clostridium difficile in horses treated with penicillin. Equine Vet J 36 (2), 180-182 PubMed.
  • Horspool L J & McKellar Q A (1995) Disposition of penicillin G sodium following intravenous and oral administration to Equidae. Br Vet J 151 (4), 401-412 PubMed.

Other sources of information

  • Bertone J & Horspool L (2004) Eds. Equine Clinical Pharmacology. Saunders. ISBN: 0702024848.
  • Derived fromThe Veterinary Formulary. (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.
  • Prescott J F, Baggot J D & Walker R D (2000) EdsAntimicrobial Therapy in Veterinary Medicine.3rd edn. Iowa State University Press.

RELATED CONTENT

Abdomen: abscess

Abdomen: peritoneal lavage

Abdomen: peritonitis

Abdomen: surgical approaches

Abortion: EHV-1

Anaphylaxis

Anemia: auto-immune hemolytic (AIHA)

Anemia: overview

Annular ligament: transection - palmar / plantar

Anthrax

Bacteroides fragilis

Bladder: urinary tract infection

Blood: agammaglobulinemia

Borrelia burgdorferi

Borreliosis

Botulism

Campylobacter spp

Cellulitis

Clostridium perfringens

Clostridium tetani

Dermatophilosis

Diarrhea: antimicrobial associated

Erysipelothrix rhusiopathiae

Ethmoid: hematoma

Eye: microbiology - overview

Eyelid: entropion

Eyelid: procaine penicillin injection - entropion

Female: minimal contamination breeding technique

Foal: neonatal maladjustment syndrome

Foal: resuscitation and care

Foot: wall resection

Gastrointestinal: clostridiosis

Guttural pouch: empyema

Immune-mediated disease: overview

Intestine: salmonellosis

Joint: septic arthritis - foal

Klebsiella pneumoniae

Larynx: arytenoidectomy

Larynx: laryngoplasty

Leptospira interrogans

Leptospirosis

Liver: cholangiohepatitis

Liver: hepatitis - necrotizing (Tyzzer's Disease)

Lung: abscess

Lung: pleuropneumonia - bacterial (pleuritis)

Lung: pneumonia - neonatal bacterial

Lymphangitis

Mammary gland: mastitis

Methotrexate

Metritis-laminitis-septicemia complex

Mouth: trauma lip - repair

Musculoskeletal: fracture - first aid

Mycoplasma spp

Navicular bursa: puncture

Nose: nasal flushing

Palmar carpal retinaculum: section

Paranasal sinus: bone flap technique

Paranasal sinus: drainage ostia - enlargement

Paranasal sinus: lavage

Paranasal sinus: percutaneous centesis

Pasteurella multocida

Patella: fracture

Penis: phallectomy - Scott's technique

Penis: phallectomy - Vinscot technique

Penis: phallectomy - William technique

Peptostreptococcus spp

Perineum: trauma - repair

Phenylbutazone

Placenta: retained

Prepuce: resection

Proteus spp

Proximal phalanx: fracture

Proximal sesamoid: fracture

Purpura hemorrhagica

Radius: fracture

Respiratory: exploratory surgery

Respiratory: meconium aspiration

Respiratory: neonatal respiratory distress syndrome

Rhodococcus equi

Scapula: fracture repair

Severe equine asthma

Skin: grafting - overview

Skin: grafting - techniques

Soft palate: palatoplasty

Soft palate: trimming

Sternum: bone graft collection

Strangles (Streptococcus equi infection)

Testis: castration - post-operative complications

Testis: castration - technique

Tetanus

Therapeutics: antimicrobials

Therapeutics: beta-lactam antibacterials

Therapeutics: intra-uterine

Therapeutics: skin

Tibia: bone graft collection

Tibia: fracture - tibial crest

Trachea: transtracheal aspiration / washing

Tuber coxae: bone graft collection

Urachus: patent

Urticaria/angiedema

Uterus: contagious equine metritis

Uterus: prolapse

Vagina: trauma

Wound: lavage

Wound: post-operative care

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code