ISSN 2398-2977      

Paracetamol

pequis

Introduction

Name

  • Paracetamol.

Class of drug

  • Aniline analgesic.
  • Non-steroidal anti-inflammatory drug (NSAID).

Description

Chemical name

  • N-(4-hydroxyphenyl)acetamide.

Molecular formula

  • C8H9NO2.

Molecular weight

  • 151.2.

Physical properties

  • White crystalline powder.
  • Clear solution.

Storage requirements

  • Do not store >30°C.
  • Store in original package.
  • Use immediately once opened.

Uses

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Indications

  • Short-term treatment of mild to moderate pain   Anesthesia: analgesia - overview  .
  • Can be used in combination with opioids and other NSAIDs to treat moderate to severe pain   Anesthesia: analgesia - opioid  .
  • Pyrexia (fever)   Pyrexia: overview  .
  • Often administered post-operatively to dogs IV as part of a multimodal analgesic plan.
  • May be considered as part of an analgesic plan and may reduce the requirement for other analgesics. However, data is lacking in the horse.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Concomitant use with anti-coagulants, eg warfarin, may lead to further prolongation of coagulation times due to a decrease in the synthesis of Vitamin K dependent clotting factors. 
  • Administration of paracetamol with other analgesic drugs (opioids and NSAIDs) leads to potentiation of analgesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • West E et al (2011) Use of acetaminophen (paracetamol) as a short-term adjunctive analgesic in a laminitic pony. Vet Anaesthesia Analgesia 38 (5), 521-522 PubMed.
  • Neirinckx E et al (2010) Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen. Res Vet Sci 89 (1), 113-119 PubMed.
  • Pickering G et al (2006) Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clin Pharmacol Therapeutics 79 (4), 371-378.
  • Greenblatt D J & Engelking L R (1988) Enterohepatic circulation of lorazepam and acetaminophen conjugates in ponies. J Pharmacol Exper Therapeutics 244 (2), 674-679 PubMed.
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