ISSN 2398-2977      

Ofloxacin

pequis

Introduction

Name

  • Ofloxacin.

Class of drug

  • Topical fluoroquinolone (second generation) antimicrobial.

Description

Chemical name

  • (+/-)-9-fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid.

Molecular formula

  • C18 H20 FN3 O4 .

Molecular weight

  • 361.368.

Physical properties

  • Clear, pale to light yellow-green solution.
  • Available as a 0.3% solution for ocular administration.

Storage requirements

  • Do not store >25°C.
  • Discard 28 days after opening.

Uses

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Indications

  • To minimize the development of resistance; the use of topical fluoroquinolones is not recommended either prophylactically or for mild disease    Therapeutics: eye  .

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • No interaction studies have been performed for this drug in humans or horses.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Chen T & Ward D A (2010) Tear volume, turnover rate, and flow rate in ophthalmologically normal horses. Am J Vet Res 71 (6), 671-676 PubMed.

Other sources of information

  • Matthews A (2004) Ophthalmic Therapeutics. In: Equine Clinical Pharmacology. Eds: Bertone J & Horspool L. pp 217-246.
  • Report a Suspect Adverse Reaction. Veterinary Medicines Directorate. Website: www.vmd.defra.gov.uk/adversereactionreporting.

RELATED CONTENT

Therapeutics: eye

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