ISSN 2398-2977      

Naloxone

pequis

Introduction

Name

  • Naloxone hydrochloride.

Class of drug

  • Pure opioid receptor antagonist.

Description

Chemical name

  • 17-Allyl-4,5alpha-epony-3,14-dihydroxymorphinan-6-one hydrochloride.

Molecular formula

  • C19H21NO4.

Molecular weight

  • 363.84 g.

Physical properties

  • Clear, sterile, aqueous solution containing 0.4 mg/ml naloxone in pre-filled syringes.
  • Solution also contains sodium chloride.

Storage requirements

  • Store <25°C.
  • Protect from light.
  • Do not freeze.

Uses

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Indications

  • To treat respiratory depression caused by opioid overdosage.
  • Compulsive endorphin-mediated disorders, eg crib-biting   Behavior: crib-biting and wind-sucking  .
  • Has been shown to improve cardiovascular function in shock in humans and other species, but did not improve hemodynamic status in endotoxemic ponies.
  • Has been investigated as a prokinetic agent.

Listed within the Substances Essential for the Treatment of Equidae (Commission Regulation 1950/2006) and therefore can be administered to horses intended for human consumption within the EU.

Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Kamerling S G, Hamra J G & Bagwell C A (1990) Naloxone-induced abdominal distress in the horse. Equine Vet J 22 (4), 241-243 PubMed.
  • Ruckebusch Y & Roger T (1988) Prokinetic effects of cisapride, Naloxone and parasympathetic stimulation at the equine ileo-caeco-colonic junction. J Vet Pharm Ther 11 (4), 322-329 PubMed.
  • Dodman N H, Shuster  L & Court M H (1987) Investigation into the use of narcotic antagonists in the treatment of a stereotypic behaviour pattern (crib-biting) in the horse. Am J Vet Res 48, 311-319 PubMed.
  • Moore A B, Roessel O F, Fessler J F et al (1983) Effects of naloxone on endotoxin-induced changes in ponies. Am J Vet Res 44, 103-109 PubMed.

Other sources of information

  • Mason D E (2004) Anesthetics, Tranquilizers and Opioid Analgesics. In: Equine Clinical Pharmacology. Eds: Berone J J & Horspool L J I. Saunders Elsevier, UK. pp 267-310.
  • Naloxone Hydrochloride Miniject® summary of product characteristics (SPC). Website: www.medicines.org.uk.
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