ISSN 2398-2977      

Latanoprost

pequis

Introduction

Name

  • Latanoprost.

Class of drug

  • Glaucoma medication.
  • Prostaglandin analogue.

Description

Chemical name

  • isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2- [(3R)3-hydroxy-5-phenylpentyl]-cyclopentyl] hept-5-enoate.

Molecular formula

  • C26 H40 O5 .

Molecular weight

  • 432.58.

Physical properties

  • Clear, colorless solution.

Storage requirements

  • Store refrigerated prior to use (2-8°C).
  • Keep the bottle in outer carton in order to protect from light.
  • After first opening, may be stored at room temperature (<25°C) and should be used within 4 weeks.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Where latanoprost is used concomitantly with other topical eye medications, there must be an interval of at least 10 min between the two medications to avoid 'second drug washout'.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Davidson H J, Pinard C L, Keil S M, Brightman A H & Sargeant J M (2002) Effect of topical ophthalmic latanoprost on intraocular pressure in normal horses. Vet Ther (1), 72-80 PubMed.
  • Willis A M, Diehl K A, Hoshaw-Woodard S et al (2001) Effects of topical administration of 0.005% latanoprost solution on eyes of clinically normal horses. Am J Vet Res 62 (12), 1945-1951 PubMed.

Other sources of information

  • Matthews A (2004) Ophthalmic Therapeutics. In: Equine Clinical Pharmacology. Eds: Bertone J & Horspool L. pp 217-246.
  • Report a Suspect Adverse Reaction. Veterinary Medicines Directorate. Website: www.vmd.defra.gov.uk/adversereactionreporting.
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