ISSN 2398-2977      

Itraconazole

pequis
Contributor(s):

Introduction

Name

  • Itraconazole.

Class of drug

  • Antifungal agent; triazole.

Uses

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Indications

Dogs and cats
  • Dermatophytosis.
  • Aspergillosis.
  • Candidiasis.
  • Blastomycosis.
  • Coccidiomycosis.
  • Cryptococcosis.
  • Histoplasmosis.
  • Refractory dermatophyte infections.
  • Systemic candidiasis.
  • Ringworm (cats).

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Dogs/Cats
Antacids
  • Itraconazole absorption may be impaired.

H2 Antagonists

  • Itraconazole absorption may be impaired.

Omeprazole  Omeprazole 

  • Itraconazole absorption may be impaired.

Adsorbents

  • Itraconazole absorption may be impaired.

Digoxin  Digoxin 

  • Plasma concentrations may be increased by itraconazole   Digoxin  .

Man

Antihistamines

  • Particularly terfenadine - metabolizm inhibited by antifungal triazoles.

Oral hypoglycemics

  • Metabolism inhibited by antifungal triazoles.

Antiepileptics

  • Metabolism inhibited by antifungal triazoles.

Cisapride

  • Metabolism inhibited by antifungal triazoles.

Cyclosporine  Cyclosporine 

  • Metabolism inhibited by antifungal triazoles.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Derived from The Small Animal Formulary (1999) 3rd edn. Ed: Tennant B. British Small Animal Veterinary Association.
  • Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.
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