ISSN 2398-2977      

Halothane

pequis

Introduction

Name

  • Halothane.

Currently unavailable.

Removed from the EU Essential List of Drugs for food-producing horses.

Class of drug

  • Inhalation anesthetic.

Description

Chemical name

  • 2-bromo-2-chloro-1,1,1-trifluoroethane.

Molecular formula

  • C2HBrCIF3.

Molecular weight

  • 197.381 g.

Physical properties

  • Liquid at room temperature.
  • Non-flammable, non-explosive.

Storage requirements

  • Unstable in light.
  • Stored in dark brown bottles.
  • Stabilizing agent 0.01% thymol - vaporizers should be serviced regularly as deposits of thymol can cause inaccurate delivery and effect vaporizer function.

Uses

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Indications

  • Inhalational anesthesia.

Do not mix with

  • Administer as a sole volatile agent vaporized in a carrier gas (oxygen or oxygen:air mixtures).

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Dysrhythmias may develop with the concurrent use of sympathomimetic agents.
  • Halothane requirement is reduced if used as part of a balanced anesthetic technique, eg following the administration of acepromazine   Cyclosporine  or alpha-2 agonists.

with diagnostic tests

  • Elevations in hepatic-derived may be elevated following administration of halothane.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Aleman M, Brosnan R J et al  (2005) Malignant hyperthermia in a horse anesthetized with halothane. J Vet Intern Med 19 (3), 363-367 PubMed.
  • Freeman S L et al (2000) Cardiopulmonary effects of romifidine and detomidine used as premedicants for ketamine/halothane anaesthesia in ponies. Vet Rec 147, 535-539 PubMed.
  • Raisis A L et al (2000) A comparison of the haemodynamic effects of isoflurane and halothane anaesthesia in horses. Equine Vet J 32 (4), 318-326 PubMed.

Other sources of information

  • Steffey E P (2009) Inhalational Anesthetics and Gases. In: Equine Anesthesia: Monitoring & Emergency Therapy. 2nd edn. Eds: Muir W W & Hubbell J A E. Saunders Elsevier, UK. pp 288-314.
  • Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.
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