ISSN 2398-2977      

Fluticasone

pequis

Introduction

Name

  • Fluticasone propionate.

Class of drug

  • Corticosteroid.

Description

Chemical name

  • S-(fluoromethyl) 6±,9-difluoro-11²,17-dihydroxy-16±-methyl-3­oxoandrosta-1,4-diene-17²-carbothioate, 17-propionate.

Molecular formula

  • C25H31F3O5S.

Molecular weight

  • 500.57.

Physical properties

  • White powder insoluble in water.

Storage requirements

  • Do not store >30degC (86degF).
  • Do not refrigerate or freeze.
  • Protect from frost and direct sunlight.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Interactions

with diagnostic tests

  • Endogenous cortisol levels may be suppressed during treatment with fluticasone.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent reference from PubMed and VetMedResource.
  • Couetil L L, Chilcoat C D, DeNicola D B, Clark S P, Glickman N W & Glickman L T (2005) Randomized, controlled study of inhaled fluticasone propionate, oral administration of prednisone and environmental management of horses with recurrent airway obstruction. Am J Vet Res 66 (10), 1665-1674 PubMed.
  • Laan T T J M, Westermann C M, Dijkstra A V, van Nieuwstadt R A & Fink-Gremmels J (2004) Biological availability of inhaled fluticasone propionate in horses. Vet Rec 155 (12), 361-364 PubMed.
  • Robinson N E, Berney C, Behan A & Derksen F J (2009) Fluticasone propionate aerosol is more effective for prevention than treatment of recurrent airway obstruction. J Vet Intern Med 23 (6), 1247-1253 PubMed.
  • Dauvillier J, Felippe M J, Lunn D P et al (2011) Effect of long-term fluticasone treatment on immune function in horses with heaves. J Vet Intern Med 25 (3), 549-57 PubMed.

Other sources of information

  • Rush B R (2004) Inhalation Therapy for the Respiratory System. In: Equine Clinical Pharmacology. Eds: Bertone J & Horspool L.
  • Rush B R & Mair T (2004) Eds. Section IV: Non-Infectious Pulmonary Disease and Diagnostic techniques. In: Equine Respiratory Disease.
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