ISSN 2398-2977      

Digoxin

pequis
Contributor(s):

Nicola Menzies-Gow


Introduction

Name

  • Digoxin.

Class of drug

  • Myocardial stimulant, cardiac glycoside.

Description

Chemical name

  • (3-beta,5-beta,12-beta)-3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1 → 4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1 → 4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide.

Molecular formula

  • C41H64O14.

Molecular weight

  • 780.9 g.

Physical properties

  • Tablets.
  • Solution.

Uses

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Indications

  • Congestive heart failure with systolic failure.
  • Supraventricular tachycardias.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Calcium salts and Hemaccel - large doses of IV calcium can precipitate arrhythmias.
  • Muscle relaxants - arrhythmias with depolarizing muscle relaxants.
  • Quinidine - enhanced effect of digoxin through decreased renal clearance, volume of distribution and affinity of tissue receptors to digoxin.
  • Antacids, cimetidine, metoclopramide, oral neomycin, albuterol and penicillinamine may decrease digoxin absorption.
  • Diazepam, propafenone, omeprazole, quinidine, anticholinergics, succinycholine, verapamil, tetracycline, phenylbutazone and erythromycin may lead to increases in digoxin levels.
  • Drugs that decrease serum potassium may predispose horses to digoxin toxicity. They include diuretics, amphotericin B, corticosteroids, ACTH, some laxatives, glucagon, dextrose or dextrose/insulin infusion, and sodium polystyrene sulfonate.
There is a narrow safety margin between the therapeutic and toxic concentrations of digoxin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.
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