ISSN 2398-2977      

Cetirizine

pequis

Synonym(s): Zyrtec


Introduction

Name

  • Cetirizine dihydrochloride.

Class of drug

  • Antihistamine H1 antagonist receptor.

Description

Chemical name

  • [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride.

Molecular formula

  • C21H27Cl3N2O3.

Molecular weight

  • 461.81.

Physical properties

  • White crystalline powder, soluble in water.

Storage requirements

  • There are no special storage requirements.

Uses

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Indications

  • Urticaria Urticaria/angioedema, physical urticaria Physical urticaria, dermatographism Dermatographism: equine studies show significant inhibition of wheal formation.
  • Reduced incidence of recurrence in eosinophilic keratitis Keratitis: eosinophilic.
  • Can be used as “corticosteroid sparing” in some pruritic horses.
  • There are anecdotal reports of effectiveness for some cases of insect bite hypersensitivity Insect hypersensitivity and seasonal headshaking Behavior: headshaking where rhinitis is a trigger factor. These claims have not been supported in clinical studies.
  • In theory, any inflammatory pathway involving Histamine H1 receptors.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Rate of excretion reduced by ivermectin Ivermectin.

With diagnostic tests

  • Effects on allergy testing are reported for hydroxyzine (cetirizine is the active metabolite) in horses.
  • A withdrawal time of 7 days is recommended prior to intradermal testing Dermatology: intradermal test.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Brom‐Spierenburg A J, Theelen M J P & Sloet van Oldruitenborgh‐Oosterbaan M M (2019) Dermatographism in a horse, responsive to cetirizine treatment. Equine Vet Educ 31 (4), 191-194 WileyOnline.
  • Brom-Spierenburg A, Mesu S & Westermann C M (2018) A randomized double-blind placebo-controlled clinical trial of Cetirizine in horses affected by seasonal headshaking. Pferdeheilkunde 34 (2), 135-140 Pferdeheilkunde.
  • Lassaline‐Utter M, Miller C & Wotman K L (2014) Eosinophilic keratitis in 46 eyes of 27 horses in the Mid- Atlantic United States (2008-2012). Vet Ophthal 17 (5), 311-320 PubMed.
  • Olsén L, Bondesson U et al (2011) Pharmacokinetics and effects of cetirizine in horses with insect bite hypersensitivity. Vet J 187 (3), 347-351 PubMed.
  • Petersen A & Schott H C II (2009) Effects of dexamethasone and hydroxyzine treatment on intradermal testing and allergen-specific IgE serum testing results in horses. Vet Derm 20 (5-6), 615-622 PubMed.
  • Olsén L, Bondesson U, Broström H, Tjälve H & Ingvast-Larsson C (2008) Cetirizine in horses: Pharmacokinetics and pharmacodynamics following repeated oral administration. Vet J 177 (2), 242-249 PubMed.
  • Olsén L, Ingvast-Larsson C et al (2007) Cetirizine in horses: pharmacokinetics and effect of ivermectin pre-treatment. J Vet Pharm Therap 30 (3), 194-200 PubMed.

Other sources of information

  • National Center for Biotechnology Information (2020) PubChem Compound Summary for CID 55182, Cetirizine hydrochloride. PubChem.
  • Scott D W & Miller W H Jr (2011) Skin Immune System and Allergic Skin Diseases. In: Equine Dermatology. 2nd edn. Saunders, USA. pp 263-313.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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