ISSN 2398-2977      

Buprenorphine

pequis

Synonym(s): Buprenorphine hydrochloride, buprenorphine hcl


Introduction

Name

  • Buprenorphine hydrochloride.

Class of drug

  • µ receptor agonist (partial agonist); opioid analgesic.

Description

Chemical name

  • (2S)-2-[(-)-(5R,6R,7R,14S_9±-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylbutan-2-ol.

Molecular formula

  • C29H41NO4.

Molecular weight

  • 467.64 g.

Physical properties

  • Clear, colorless, aqueous solution for injection.

Storage requirements

  • Store <25°C.
  • Protect from light.
  • Keep in outer carton.
  • Controlled drug with addiction potential.
  • Store in accordance with legislative guidance.

Uses

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Indications

The analgesia associated with buprenorphine is known to reach a 'ceiling'. In a case of continuing pain, administering a further dose of buprenorphine may not be effective.

Drugs from other classes should be considered, although pain management may become more difficult due to the high affinity of buprenorphine for the µ receptor, and its long duration of action.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Synergism with other CNS depressants (sedatives and anesthetics).

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • ​Love E J, Taylor P M, Whay H R & Murrell J (2013) Postcastration analgesia in ponies using buprenorphine hydrochloride. Vet Rec 172 (24), 635 PubMed.
  • Love E J, Taylor P M, Murrell J, Whay H R & Waterman-Pearson A E (2011) Assessment of  the sedative effects of buprenorphine administered with 10 µg/kg detomidine in  horses. Vet Rec 168 (14), 379 PubMed.
  • Love E J, Taylor P M, Murrell J, Whay H R & Waterman-Pearson A E (2011) Assessment of the sedative effects of buprenorphine administered with 20 µg/kg detomidine in horses. Vet Rec 168 (15), 409 PubMed.
  • Murrel J C, Robertson S A, Taylor P M et al (2007) Use of a transdermal matrix patch of buprenorphine in cats: preliminary pharmacokinetic and pharmacodynamic data. Vet Rec 160 (17), 578-583 PubMed.
  • Walker A F (2007) Sublingual administration of buprenorphine for long-term analgesia in the horse. Vet Rec 160 (23), 808-809 PubMed.

Other sources of information

  • Love E J, Murrell J, Whay H R & Taylor P M  (2008) Antinociceptive Effects of Buprenorphine in Horses: A Dose Finding Study. In: Abstracts Presented at the American College of Veterinary Anesthesiologists. Autumn Conference, USA. pp 14.
  • Taylor P M, Love E J, McCluskey L, Whay H R & Murrell J (2008) Analgesic Effects of Buprenorphine Following Castration in Ponies. In: Abstracts Presented at the American College of Veterinary Anesthesiologists. Autumn Conference, USA. pp 15.
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