ISSN 2398-2977      

Amphotericin B

pequis
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Introduction

Name

  • Amphotericin B.

Class of drug

  • Anti-fungal antibiotic; polyene.

Description

Molecular formula

  • C47H73NO17.

Physical properties

  • Yellow powder/tablets or solution.

Storage requirements

  • Loss of drug activity is negligible for at least 8 hours in room light.
  • After reconstitution the preparation is stable for 1 week if refrigerated and stored in the dark.

Uses

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Indications

Dogs and cats
  • Serious systemic mycoses - yeast and fungal infections.
  • Fungal septicemia.
  • Fungal urinary tract infections.
  • Intestinal candidiasis (man).
  • Candida infections.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Dogs and cats
Nephrotoxic drugs
  • Do not use concurrently.
Electrolyte solutions
  • Physically incompatible.
Cisplatin
  • May increase the toxic effects of cisplatin.
Fluorouracil
  • May increase the toxic effects of fluorouracil.
Doxorubicin
  • May increase the toxic effects of doxorubicin.
Methotrexate Methotrexate
  • May increase the toxic effects of methotrexate.
Flucytosine

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Derived from The Small Animal Formulary (1999) 3rd edn. Ed: Tennant B. British Small Animal Veterinary Association.
  • Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.
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