ISSN 2398-2977      

Gastrointestinal: ileus

pequis
Contributor(s):

Prof Jonathon Naylor

Synonym(s): Paralytic colic


Introduction

  • Ileus is defined as a failure of gut motility.
  • It can be a cause of colic, and can also be a post-operative complication of colic surgery.
  • Cause: possibilities include grass sickness, electrolyte disturbances and other agents which interfere with motility.
  • Signs: abdominal pain, anorexia, lack of defecation and nasogastric reflux.
  • Diagnosis: clinical signs and history.
  • Treatment: some cases are refractory to treatment, but the treatment of choice is generally cisapride.
  • Prognosis: guarded.

Pathogenesis

Etiology

  • Grass sickness   Grass sickness  causes degenerative changes in the sympathetic ganglia   →   increase in sympathetic tone   →   in loss of intrinsic progressive motility of bowel.
  • Gastrointestinal surgery, anterior enteritis   Intestine: enteritis  and peritonitis   Abdomen: peritonitis  can all predispose to the development of ileus.

Predisposing factors

General

Pathophysiology

  • Loss of intrinsic gut motility that causes peristalsis.
  • Gut stasis results, and behaves like functional obstruction.
  • Severe symptoms of abdominal pain, dehydration and circulatory collapse can develop.
  • In cases that do not respond to treatment euthanasia   Euthanasia  may be the only option.
  • Ileus can result from changes in sympathetic tone in the bowel (in grass sickness) but can also result from the actions of other biochemical compounds on bowel wall receptors.
  • Presence of endotoxins   Endotoxemia: overview  , hypocalcemia   Hypocalcemia  and hypokalemia   Blood: biochemistry - potassium  all have recognized involvement in the development of ileus.
  • Ileus involves the paralysis of the bowel (particularly small intestine) wall. This results in a failure of movement of bowel wall contents. The resulting stretching of the bowel wall, which would normally initiate a peristaltic wave, because excessive and further impairs motility. In addition, dehydration and bowel stasis predispose to the development of further endotoxemia, hypocalcemia and hypokalemia, which can predispose to the development of more serious ileus.
  • Fluid build up or tympany can result, and can   →   gut rupture   Stomach: rupture  .

Timecourse

  • Disease generally becomes life threatening within 2-3 days of inciting cause.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Hillyer M H, Smith M R W & Milligan P J P (2008) Gastric and small intestinal ileus as a cause of acute colic in the post parturient mare. Equine Vet J 40 (4), 368-372 PubMed.
  • Roussel A J, Cohen N D, Hooper R N & Rakestraw P C (2001) Risk factors associated with development of postoperative ileus in horses. JAVMA 219 (1), 72 PubMed.
  • Merritt A M, Burrow J A & Hartless C S (1998) Effect of xylazine, detomidine and a combination of xylazine and butorphanol on equine duodenal motility. Am J Vet Res 59 (5), 619-623 PubMed.
  • Evans D (1998) Gastric emptying and adynamic ileusEquine Vet J 30 (4), 278-279 PubMed.
  • Dart A J et al (1998) Role of prokinetic drugs for treatment of postoperative ileus in the horse. Aust Vet J 76 (1), 25-31 PubMed.
  • Hillyer, M H et al (1997) Recurrent colic in the mature horse - a retrospective review of 58 cases. Equine Vet J 29 (6), 421-424 PubMed.
  • King J N & Gerring E L (1991) The action of low dose endotoxin on equine bowel motility. Equine Vet J 23 (1), 11-17 PubMed.
  • Gerring E L (1991) All wind and water - some progress in the study of equine gut motility. Equine Vet J 23 (2), 81-85 PubMed.

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