ISSN 2398-2977      

Colon: inflammation - right dorsal

pequis

Synonym(s): RDC, right dorsal colitis, NSAID toxicity


Introduction

  • Cause: strong association with previous NSAID therapy.
  • Signs: inappetance, anorexia, weight loss, spasmodic colic, ventral edema, diarrhea.
  • Diagnosis: history and clinical signs, abdominal ultrasonography, celiotomy.
  • Treatment: medical management if diagnosed early.
  • Prognosis: fair provided good owner compliance.

Pathogenesis

Etiology

  • Administration of phenylbutazone   Phenylbutazone  , even at recommended dosages for as little as 1 week.
  • Other non-steroidal anti-inflammatory drugs   Toxicity: non-steroidal anti-inflammatory (NSAID)  , eg flunixin meglumine   Flunixin meglumine  .
  • Toxicity resulting from the simultaneous administration of two or more non-steroidals (stacking); toxicity is cumulative and can result even if each drug is administered at label dosages.
  • Non-steroidal toxicity   Toxicity: non-steroidal anti-inflammatory (NSAID)  resulting from overdosage, usually chronic rather than acute.
  • Specific pathophysiology of right colon involvement is unknown.

Predisposing factors

General
  • Stress may increase risk.

Specific

  • High protein diet.
  • Genetic predisposition.
  • Dehydration.
  • Concurrent administration of other drugs.

Pathophysiology

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Johns I (2010) Typhlocolitis in donkeys and horses. Equine Vet Educ 22 (1), 60-61 Wiley Online Library.
  • Jones S, Davis J & Rowlingson K (2003) Ultrasonographic findings in horses with right dorsal colitis: five cases (2000-2001). JAVMA 222 (9), 1248-1251 PubMed.
  • Hough M, Steel C, Bolton J & Yovich J (1999) Ulceration and stricture of the right dorsal colon after phenylbutazone administration in four horses. Aust Vet J 77 (12), 785-788 PubMed.

Other sources of information

  • Robinson N & Sprayberry K (2009) Current Therapy in Equine Medicine 6. Saunders Elsevier.
  • Mair T, Divers T & Ducharme N (2002) Manual of Equine Gastroenterology. W B Saunders.

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