ISSN 2398-2977      

Cecum: typhlitis

pequis

Introduction

Pathogenesis

Etiology

Predisposing factors

General

Specific

Pathophysiology

  • Colonization of the intestinal mucosa by pathogenic bacteria (Salmonellaspp   Salmonella spp  ,Clostridium difficile  Clostridium difficile  ,Clostridium perfringens  Clostridium perfringens  )   →   mucosal inflammation and injury.
  • Inflammation   →    intestinal dysfunction manifested as ileus   Gastrointestinal: ileus  and also results in fluid shifts into the intestinal lumen   →    diarrhea and dehydration.
  • In severe cases the loss of mucosal barrier function combined with suppression of the patient's immune response can allow for the establishment of systemic fungal infections, most commonlyAspergillus  Aspergillus spp  infections.
  • In the case of parasite-associated typhlitis, the excysting of L4 cyathostome larvae within the intestinal mucosa   →    potentially severe mucosal inflammation followed by dysfunction as described above.

Timecourse

  • Acute to subacute.
  • Rarely chronic, but can be associated with cyathostomiasis.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Johns I (2010) Typhlocolitis in donkeys and horses. Equine Vet Educ 22 (1), 60-61 Wiley Online Library.
  • Chapman A (2009) Acute diarrhea in hospitalized horsesVet Clin North Am Equine Pract 25 (2), 363-380 PubMed.

Other sources of information

  • Robinson N & Sprayberry K (2009) Therapy in Equine Medicine 6. Saunders Elsevier.

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