ISSN 2398-2977      

Atypical myoglobinuria

pequis
Contributor(s):

Graham Munroe


Introduction

  • Severe, often fatal, attacks of a syndrome similar to equine rhabdomyolysis syndrome   Muscle: myopathy - exertional rhabdomyolysis  .
  • Groups of horses/ponies at pasture are affected with no history of exercise.
  • Cause: unknown etiology, but environmental and/or toxic causes are possibilities.
  • Signs: sudden onset of stiffness, unrelated to exercise, rapidly followed by severe myoglobinuria, profound weakness/recumbency and death.
  • Diagnosis: markedly elevated muscle enzymes and myoglobinuria.
  • Treatment: symptomatic.
  • Prognosis: poor.

Pathogenesis

Etiology

  • Unknown but thought to be of environmental/toxic nature.
  • Adverse weather conditions prior to outbreak.
  • Availability of tree bark, especially on dead wood.

Predisposing factors

General
  • Adverse weather conditions.
  • Availability of tree bark, especially on dead wood.

Specific

  • Trichodermafungi isolated from grass/wood taken from grazed fields. ?Mycotoxins.

Pathophysiology

  • Severe, often fatal, attacks of a similar condition to equine rhabdomyolysis syndrome   Muscle: myopathy - exertional rhabdomyolysis  in groups of animals at pasture.
  • Unknown etiology but thought to be of environmental and/or toxic nature.
  • General and specific predisposing factors may suggest the presence of increased levels of mycotoxin.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • van Galen G, Serteyn D, Amory H & Votion D M (2008) Atypical myopathy: New insights into the pathophysiology, prevention and management of the condition. Equine Vet Educ 20 (5), 234-238 VetMedResource.
  • Sherlock C E & Mair T S (2008) Concurrent atypical myoglobinuria and colon displacement in a filly. Equine Vet Educ 20 (5), 228-233 VetMedResource.
  • Whitwell K E, Harris P A & Harrington P G (1988) Atypical myoglobinuria: an acute myopathy in grazing horsesEquine Vet J 20, 357 PubMed.
  • Hosie B D et al (1986) Acute myopathy in horses at grass in east and south-east Scotland. Vet Rec 119, 444-449 PubMed.

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