Canis ISSN: 2398-2942

Bone marrow aspiration

Synonym(s): Bone marrow biopsy

Contributor(s): Kyle Braund

Introduction

  • To obtain a bone marrow sample as an aid to diagnosis - either as an aspirate (cytology) or core (histopathology) biopsy.

Uses

  • Aid in etiological diagnosis of non-regenerative anemias Anemia: non-regenerative , leukemias Leukemia , myeloma Myeloma and pancytopenias. Bone marrow aspirates provide cytologic specimens for evaluation of cellularity, eg in cases of leukemia, dysplasias and maturation defects, whereas core biopsies are useful for diagnosis of myelofibrosis, metastatic neoplasia, lymphoma, infections granuloma and megakaryocyte number, etc.
  • Adjunct to the staging of neoplasms such as lymphoma Lymphoma.

Advantages

  • Not a difficult procedure.
  • Samples can be obtained from several sites: wing of ileum (described here), femur and the humeral head, or proximal tibia.

Disadvantages

  • One random sample could miss focal or multifocal disease.

Requirements

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Preparation

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Procedure

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Aftercare

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Villiers E J & Dunn J K (1999) Clinicopathological features of seven cases of canine myelofibrosis and the possible relationships between the histological findings and prognosis. Vet Rec 145 (8), 222-228 VetMedResource.
  • Dunn J K (1992) Bone marrow aspiration and biopsy in small animals - indications and techniques. Vet Ann 32, 107-118 VetMedResource.

Other sources of information

  • O'Keefe D A (1992) Bone marrow biopsy - indications and techniques. In: Kirk's Current Veterinary Therapy, Volume 6. Ed J D Bonagura. Philadelphia, PA: W B Saunders Co. pp 488-492.


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