Canis ISSN: 2398-2942

Urine cortisol:creatinine ratio

Contributor(s): Vetstream Ltd

Overview

  • Dogs with elevated [blood cortisol] have elevated [corticosteroid metabolites] in urine.
  • Measurement of [corticosteroid metabolites] in 24 hour urine collections discriminates healthy dogs from those with hyperadrenocorticism.
  • Difficulty collecting 24 hour urine sample limits use of this technique.

Sampling

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Tests

Methodologies

  • Radioimmunoassay for cortisol.

Availability

  • Widely available at commercial laboratories.

Validity

Sensitivity

  • Highly sensitive in discriminating normal dogs from those with hyperadrenocorticism.

Specificity

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Gupthill L, Scott-Montcrieff J C, Bottoms G, Glickman L, Johnson M, Glickman N, Nelson R & Bertoy E (1997) Use of urine cortisol - creatinine ratio to monitor treatment response in dogs with PDH. JAVMA 210, 1158-1161.


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