Canis ISSN: 2398-2942

Urinalysis: ketone

Synonym(s): Ketone body

Contributor(s): David Bruyette, Kathleen P Freeman

Overview

  • Normally absent from blood and urine → presence indicates shift in energy production from carbohydrates to fat.
  • Readily excreted in urine and becomes 5% more concentrated in plasma.
  • Accurate way to detect ketosis.

Sampling

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Tests

Methodologies

Dipstick

  • Immerse dipstick in urine until wet.
  • Remove and shake off excess urine.
  • Hold horizontally to avoid run-off between pads.
  • Read test at correct time interval.

Assay

  • Usually measured in urine rather than plasma.

Availability

  • All veterinary practices.
  • External laboratories.

Validity

Sensitivity

This test only detects acetone and acetoacetone. Since beta-hydroxybutyrate is often the first ketone to be released in ketoacidosis, this makes the ketone dipstick insensitive.

Specificity

  • Good.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Brobst D (1989) Urinalysis and associated laboratory procedures. Vet Clin North Am Small Anim Pract 19(5), 929-949.
  • McCaw D L, Fleming E J & Mikiciuk M G (1989) Interpreting the results of urinalysis - a key to diagnosing renal disorders. Vet Med 84(3), 281-286.


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