Canis ISSN: 2398-2942

Urinalysis: hemoglobin

Contributor(s): Kathleen P Freeman

Overview

  • Hemoglobin filtered by the glomeruli (true hemoglobinuria Hemoglobinuria ) or hemoglobin released by lysis of erythrocytes (hematuria) will result in free hemoglobin being detected in the urine.
  • Produces positive protein and blood Urinalysis: dipstick analysis reactions on a dipstick.
  • Hemoglobin may precipitate in the kidney tubules → casts visible in urine sediment Urinalysis: centrifuge sediment.
  • Quantitative assessment of hemoglobinuria can be carried out by commercial diagnostic laboratories using chromotography techniques.

Sampling

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Tests

Methodologies

Dipstick

Microscopic examination

Chemical analysis

  • Chemical tests may be necessary to distinguish hemoglobinuria from myoglobinuria Myoglobinuria.

Availability

Dipstick

  • All veterinary practices.

Microscopic examination

  • Some veterinary practices.
  • Commercial laboratories.

Chemical analysis

  • Commercial laboratories.

Validity

Specificity

  • Dipstick: hemoglobinuria, myoglobinuria and free red blood cells will induce a positive reaction on dipstick test.
  • Visual color assessment is prone to individual technician variation in interpretation.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Brobst D (1989) Urinalysis and associated laboratory procedures. Vet Clin North Am Small Anim Pract 19(5), 929-949.
  • McCaw D L, Fleming E J & Mikiciuk M G (1989) Interpreting the results of urinalysis - a key to diagnosing renal disorders. Vet Med 84(3), 281-286.

Other sources of information

  • Kaneko J J (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Harvey J W & Bruss M L (eds). Academic Press, Boston.
  • Duncan J R, Prasse K W & Mahaffy E A (1994) Veterinary Laboratory Medicine Clinical Pathology. 3rd edn. Iowa University Press, Ames, Iowa.


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