Canis ISSN: 2398-2942

PTH assay

Contributor(s): David Bruyette, Peter Graham

Overview

  • Parathyroid hormone (PTH) released from parathyroid glands.
  • Plasma calcium usually operates negative feedback system on PTH release.
  • Multiple metabolic fragments of PTH in circulation are cleared by glomerular filtration.
  • Only intact PTH molecule is active.

Sampling

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Tests

Methodologies

  • Radioimmunoassay (RIA).
  • Modern assay is a sensitive 2-site intact PTH assay:
    • Measures functional parathyroid output.
    • Less increase in PTH in renal failure (most increase is due to retention of inactive fragments).

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Torrance A G & Nachreiner R (1989) Human parathyroid assay for use in dog - validation, sample handling studies and parathyroid function testing. Am J Vet Res 50, 1123-1127.
  • Torrance A G & Nachreiner R (1989) Intact parathyroid assay and total calcium concentration in the diagnosis of disorders of calcium metabolism in dogs. JVIM 3, 86-89.


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