Canis ISSN: 2398-2942

Hematology: nucleated red blood cell

Synonym(s): Rubricyte, Normoblast, Erythroblast, Metarubricyte, nRBC, Prorubricyte

Contributor(s): Kathleen P Freeman

Overview

  • Immature RBCs which precede reticulocytes, can be polychromatic or orthochromatic; can have a very open chromatin (nuclear contents) pattern and small amount of cytoplasm.
  • Presence of large numbers always significant, except some Miniature Schnauzers Schnauzer: miniature.

Sampling

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Tests

Methodologies

  • See differential WBC count.
  • Romanowsky stain.

Availability

  • Widely available at commercial laboratories.
  • Blood smear examination can be performed in practice.

Validity

Sensitivity

  • Depends on experience of cytologist in recognizing cells.

Specificity

  • Good.

Predictive value

  • High - always significant finding if in large numbers.

Technician (extrinsic) limitations

  • Require some cytological experience to identify cells accurately.

Result Data

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Further Reading

Publications

Refereed papers

Other sources of information

  • Cowell R J, Tyler R D & Meinkoth J H (1999) Diagnostic Cytology and Hematology of the Dog and Cat. 2nd edn. St Louis: Mosby.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine Clinical Pathology. 3rd edn. Ames, Iowa: Iowa University Press.
  • Jain N C (1993) Essentials of Veterinary Hematology. Philadelphia: Lea & Febiger.


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