ISSN 2398-2942      

Hematology: neutrophil

icanis

Overview

  • Neutrophils phagocytose and digest foreign material in acute infectious or non-infectious inflammation.
  • The degree of [neutrophil] increase (neutrophilia) and presence or absence of left-shift provides a valuable diagnostic (in combination with other tests) and prognostic tool in many diseases.
  • Regenerative left-shift: neutrophilia with increased numbers of bands (mature neutrophils usually outnumber bands Hematology: band neutrophil, band cell ).
  • Degenerative left-shift: increased numbers of bands without increased numbers of mature neutrophils. Presence indicates that production and release are not meeting demand.
  • Marked left-shift (bands and metamyelocytes) Hematology: band neutrophil, band cell → acute to peracute, suppurative diseases. Any stage younger than the metamyelocyte is not capable of phagocytosis.
  • Neutrophils are short-lived (approximately 4 days).

Sampling

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Tests

Methodologies

  • Manual hemocytometer - accuracy +/- 20-25%.
  • Electronic counting systems - accuracy +/- 3-5% (intralaboratory precision) or +/- 10-15% (interlaboratory precision).
  • Some in-practice analyzers or cell counting methods available.

Availability

  • Widely available at commercial laboratories.
  • May be performed in practice.

Validity

Sensitivity

  • Sensitive.

Specificity

  • Non-specific.

Predictive value

  • Useful if used in conjunction with differential white blood cell counts.

Technician (extrinsic) limitations

  • Some experience is required for accurate identification of leukocytes.

Result Data

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Schnelle A N & Barger A M (2012) Neutropenia in dogs and cats: causes and consequences. Vet Clinics North Am Small Anim Pract 42 (1), 111-122 PubMed.
  • Brown M R & Rogers K S (2001) Neutropenia in dogs and cats - a retrospective study of 261 cases. JAAHA 37, 131-139.

Other sources of information

  • Valenciano A C & Cowell R E (2013) Cowell and Tyler's Diagnostic Cytology and Hematology of the Dog and Cat. 4th edn, Mosby, USA.
  • Day N & Kohn B (2012) BSAVA Manual of Canine and Feline Haematology and Transfusion Medicine. 2nd edn. BSAVA, UK.
  • Latimer K S (2011) Duncan and Prasse's Veterinary Laboratory Medicine: Clinical Pathology. 5th edn. Iowa University Press, Ames, Iowa.
  • Stockham S L & Scott M A (2008) Fundamentals of Veterinary Clinical Pathology. 2nd edn. Blackwell Publishing.
  • Jain N C (1993) Essentials of Veterinary Hematology. Lea & Febiger, Philadelphia.

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code