Canis ISSN: 2398-2942

Hematology: lymphocyte

Synonym(s): Haematology

Contributor(s): Kathleen P Freeman

Overview

  • T-lymphocytes (cell-mediated immunity) and B-lymphocytes (precursors of plasma cells) - humoral antibody/immunoglobulin production populations; a small, third group are 'null' cells - function unknown.
  • May not be differentiated on the basis of light microscopic morphology alone.
  • T-lymphocytes, in particular, can recirculate between blood and lymph nodes.

Sampling

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Tests

Methodologies

  • Manual hemocytometer - accuracy +/- 20-25%.
  • Electronic counting systems - accuracy +/- 3-5% (intralaboratory precision) or +/- 10-15% (interlaboratory precision).
  • Some in-practice analyzers or cell counting methods available.

Availability

  • Widely available at commercial laboratories.

Validity

Sensitivity

  • Sensitive.

Specificity

  • Non-specific.

Predictive value

  • Non-specific.

Technician (extrinsic) limitations

  • Some experience is required for accurate identification of leukocytes.

Result Data

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Further Reading

Publications

Refereed papers

Other sources of information

  • Cowell R L, Tyler R D & Meinkoth J H (1999) Diagnostic Cytology and Hematology of the Dog and Cat. 2nd edn. Mosby, St Louis.
  • Duncan J R, Prasse K W & Mahaffy E A (1994) Veterinary Laboratory Medicine Clinical Pathology. 3rd edn. Iowa University Press, Ames, Iowa.
  • Jain N C (1993) Essentials of Veterinary Hematology. Lea & Febiger, Philadelphia.


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