Canis ISSN: 2398-2942

Blood biochemistry: triglycerides

Contributor(s): Kathleen P Freeman

Overview

  • Most common form in which lipid is stored.
  • Synthesized in:
    • Intestinal mucosa (exogenous triglyceride) → carried to tissues as chylomicrons.
    • Liver (endogenous triglyceride) → carried to tissues as very low density lipoproteins (VLDL).
  • Both forms hydrolyzed in capillary endothelium by lipoprotein lipase (LDL) and free fatty acids → taken into cells.
  • LDL activity increased by insulin, glucagon and thyroid hormones → lipemia may indicate decreased activity of one of these hormones.
  • Cloudy serum is caused by hypertriglyceridemia.

Sampling

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Tests

Methodologies

  • Spectrophotometric or enzymatic method: breaks down triglyceride and measures glycerol produced.

Availability

  • Widely available.

Technique (intrinsic) limitations

  • Results only significant when interpreted in conjunction with other laboratory results.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Chikamune T (1998) Lipoprotein profile in canine pancreatitis induced with oleic acid. J Vet Med Sci 60(4), 413-421.
  • Ford R B (1993) Ideopathic hyperchylomicronemia in Miniature Schnauzers. JSAP 39, 488.
  • Watson T D & Barrie J Lipoprotein metabolism and hyperlipidemia in the dog and cat. JSAP 34, 479 (Review).

Other sources of information

  • Ettiger S J & Feldman E C (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphi: Saunders and Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.


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