Canis ISSN: 2398-2942

Blood biochemistry: lactate dehydrogenase

Synonym(s): LD, Serum LDH, SLDH

Contributor(s): Vetstream Ltd

Overview

  • Comprises 5 isoenzymes found principally in skeletal muscle, cardiac muscle, liver and red blood cells - not organ specific, but may be useful in assessment of muscle damage.
  • LDH, and LDH2 - heart, RBCS, kidney, CNS.
  • LDH3 - lung, pancreas, adrenal, spleen, thyroid gland.
  • LDH4, and LDH5 - skeletal muscle, liver.
  • Longer half-life than creatine phosphokinase Blood biochemistry: creatine phosphokinase.

Sampling

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Tests

Methodologies

  • Varies between laboratories (electrophoresis needed for LDH isoenzymes).

Availability

  • Widely available.

Validity

Specificity

LDH without isoenzymes is so non-specific that it is rarely interpretatively useful.

Technique (intrinsic) limitations

  • Test results most useful when interpreted in conjunction with other laboratory results and clinical findings.

Result Data

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Further Reading

Publications

Refereed papers

Other sources of information

  • Kaneko J J (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Eds: J W Harvey & M L Bruss. Academic Press, Boston.


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