Canis ISSN: 2398-2942

Blood biochemistry: gamma glutamyltransferase

Synonym(s): gGT, Gamma glutamyltranspeptidase, GTP

Contributor(s): Kathleen P Freeman

Overview

  • Membrane-associated enzyme.
  • Highest levels in renal tubular epithelial cells, canalicular surfaces of hepatocytes and bile duct epithelium - also present in pancreas and small intestine.
  • Hepatobiliary system is main source of serum GGT in health and disease.

Sampling

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Tests

Methodologies

  • Vary between laboratories.

Availability

  • Widely available.

Validity

Sensitivity

  • Lower sensitivity than ALP in detection of liver disease, but greater specificity.

Specificity

  • Lower sensitivity than ALP in detection of liver disease, but greater specificity.

Technique (intrinsic) limitations

  • Test results most significant in conjunction with other laboratory results and clinical findings.
  • Canine colostrum contains large amounts of GGT; with colostral absorption in neonates see marked increases in GGT levels (<1000X).

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Center S A, Slater M R, Mainwarren T et al (1992) Diagnostic efficacy of serum alkaline phosphatase and gamma-glutamyltransferase in dogs with histologically confirmed hepatobiliary disease - 270 cases (1980-1990). JAVMA 201, 1258.

Other sources of information

  • Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: W B Saunders & Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.


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