Canis ISSN: 2398-2942

Blood biochemistry: gamma globulin

Synonym(s): IgG

Contributor(s): Kathleen P Freeman

Overview

  • Immunoglobulins produced by plasma cells and have important role in immune system.
  • Four distinct classes:
    • IgG most abundant (mediates systemic infection).
    • IgM major immunoglobulin produced in primary immune response.
    • IgA important in external secretions (protect intestine, respiratory and urogenital tracts).
    • IgE (proliferation of a single clone of plasma cells → homogenous protein produced).
  • Detection of:

Sampling

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Tests

Methodologies

  • Serum protein electrophoresis (does not identify classes; quantifies total globulins).
  • Immunoelectrophoresis: separating plasma/serum proteins.
  • Radial immunodiffusion (most accurate quantification, usually class specific identification of immunoglobulin pursued).

Availability

  • Serum protein electrophoresis done at most commercial laboratories.
  • Immunoelectrophoresis or radial immunodiffusion less widely available.
  • Call laboratory to determine availability prior to submission.

Technique (intrinsic) limitations

  • Test results only significant in conjunction with other laboratory and clinical findings.

Technician (extrinsic) limitations

  • Electrophoresis: sophisticated technique.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Font A (1996) Consider leishmaniasis in differential for monoclonal gammopathies in dogs. JAVMA 208, 104-107.

Other sources of information

  • Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: W B Saunders & Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.


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