Canis ISSN: 2398-2942

Blood biochemistry: folate

Contributor(s): Marge Chandler, Kathleen P Freeman

Overview

  • Water soluble B vitamin absorbed in upper small intestine.
  • Dietary deficiency unlikely; [serum] reflect absorption in intestine.
  • Plentiful in most commercial pet foods.
  • Dietary levels can influence fasting serum levels, leading to an increase in fasting serum levels.

Sampling

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Tests

Methodologies

  • Radioimmunoassay.
  • Chemiluminescent immunoassay.
  • Bioassay.

Availability

  • Available at many commercial laboratories.

Validity

Sensitivity

  • Low sensitivity (estimated to be approximately 5%).

Specificity

  • High specificity.
  • Sensitivity and specificity are improved when combined interpretation with serum vitamin B12 determination.

Technique (intrinsic) limitations

  • Interpret in conjunction with other tests (especially vitamin B12/cobalamin and TLI), and in conjunction with clinical signs, presentation and history.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • German A J, Day M J, Ruaux C G et al (2003) Comparison of direct and indirect tests for small intestinal bacterial overgrowth and antibiotic-responsive diarrhea in dogs. J Vet Intern Med 17, 33-43 PubMed.

Other sources of information

  • Ettinger S J & Feldman E C (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: Saunders and Co.
  • Simpson J W (1998) Gastrointestinal system and exocrine pancreas. In: Manual of Small Animal Clinical Pathology. Davidson M, Else R & Lumsden J (eds). BSAVA, Cheltemham.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Bush B M (1991) Interpretation of Laboratory ResultsBlackwell Scientific Publications, Oxford.


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