Canis ISSN: 2398-2942

Blood biochemistry: direct bilirubin

Synonym(s): Conjugated bilirubin

Contributor(s): Kathleen P Freeman

Overview

  • Serum bilirubin Blood biochemistry: total bilirubin is a mixture of direct (conjugated) and indirect (uncongugated) bilirubin.
  • Peripheral breakdown of red cells and myoglobin → uncongugated bilirubin → (liver) conjugated with glucuronic acid → excreted in bile as conjugated (direct) bilirubin.
    In animals there is little evidence that ratio of direct:indirect bilirubin is significant.
  • Conjugated hyperbilirubinemia occurs in the dog and cat even in hemolytic disease.

Sampling

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Tests

Methodologies

  • Van den Bergh method.

Availability

  • Widely available at commercial laboratories.

Validity

Sensitivity

  • Van den Bergh test relatively insensitive.

Technique (intrinsic) limitations

  • Most useful when interpreted in conjunction with other laboratory and clinical findings.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Anderson J G & Washabau (1992) Icterus. Comp Cont Educ Pract Vet 14(8), 1045-1061.
  • Engelking L R (1988) Disorders of bilirubin metabolism in small animal species. Comp Contin Educ Pract Vet 10, 712.

Other sources of information

  • Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: W B Saunders & Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.


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