Overview

• Occurs as 3 isoenzymes in skeletal muscle, cardiac muscle and central nervous system (CNS):
  • CK1 (BB) in brain, peripheral nerve, cerebrospinal fluid and viscera. Not found in serum.
  • CK2 (MB) in cardiac muscle; very small amounts in skeletal muscle.
  • CK3 (MM) in skeletal and cardiac muscle.
• Most sensitive indicator of muscle damage.
• Levels peak 6-12 hours post-injury, returning to normal in 2-3 days after cessation of injury. Persistent elevation indicates continuing or active disease.

Sampling

Tests

Methodologies

• Methods (and reference interval) vary between laboratories.
• Enzymatic/spectrophotometric measurement.

Availability

• Widely available at commercial laboratories.

Result Data

Further Reading

Publications

Refereed papers

• Recent references from VetMedResource and PubMed.
• Aktas M, Auguste D, Concordet D et al (1994) Creatinine kinase in dog plasma - preanalytical factors of variation, reference values and diagnostic significance. Res Vet Sci 56, 30.

Other sources of information

• Ettinger S J & Feldman E C (2000) Eds. Textbook of Veterinary Internal Medicine. 5th edn. W B Saunders & Co, USA.
• Kaneko J J, Harvey J W & Brass M L (1997) Eds. Clinical Biochemistry of Domestic Animals. 5th edn. Academic Press, USA.
• Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa University Press, USA.