Canis ISSN: 2398-2942

Blood biochemistry: alanine aminotransferase (SGPT, ALT)

Synonym(s): ALT, Serum ALT, SALT, Glutamic-pyruvic transaminase, GPT, Serum GPT, SGPT

Contributor(s): Vetstream Ltd

Overview

  • ALT may be elevated with liver or muscle damage/disease.
  • Highest concentration in hepatocytes, so considered most sensitive for hepatocellular damage.
  • Transaminase (similar to AST).
  • No isoenzymes.
    Follow the diagnostic tree for Elevated Serum Transaminases in Asymptomatic Patients Elevated Serum Transaminases in Asymptomatic Patients.

Sampling

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Tests

Availability

  • Widely available.

Technique (intrinsic) limitations

  • Results best interpreted in conjunction with other laboratory tests and clinical findings.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Sivenson C L & Graves T K (1997) Absence of liver specificity for canine alanine aminotransferase (ALT). Vet Clin Pathol 26(1), 26-28.

Other sources of information

  • Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: W B Saunders & Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.


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