Canis ISSN: 2398-2942

Vincristine

Contributor(s): William Brewer Jr, Vetstream Ltd

Introduction

Name

  • Vincristine sulfate.

Class of drug

  • Vinca alkaloid antineoplastic agent, derived from the periwinkle plant (Vinca rosea).

Description

Physical properties

  • White or yellow water soluble powder.

Storage requirements

  • Keep refrigerated.
  • Protect from light.

 

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Asparaginase

  • May cause additive bone marrow suppression.

Cisplatin Cisplatin or Paclitaxel

  • May increase neurotoxicity.

Digoxin

  • May decrease serum levels and effects of digoxin Digoxin.

with diagnostic tests

  • Increases blood and urine concentrations of uric acid.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Grau-Bassas E R et al (2000) Vincristine impairs platelet aggregation in dogs with lymphoma. J Vet Intern Med 14, (1) 81-5.

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA.
  • Fischer D S, Knobf M T et al (2003) The Cancer Chemotherapy Handbook.6th edn. Philadelphia, PA, Mosby. pp 234-236.

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