ISSN 2398-2942      

Torasemide

icanis

Synonym(s): UpCard, Isemid, torsemide


Introduction

Name

  • Torasemide.

Class of drug

  • Loop diuretic of the pyridyl sulfonylurea class.

Description

Chemical name

  • 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea.

Molecular formula

  • C16H20N4O3S

Molecular weight

  • 348.42

Physical properties

  • White to off-white tablets.

Storage requirements

  • No specific storage requirements.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

For dogs in acute crisis with pulmonary edema, pleural effusion and/or ascites requiring emergency treatment, use of injectable drugs should be considered first before commencing oral diuretic therapy.

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

With other drugs

  • Co-administration of loop diuretics and NSAIDs Analgesia: NSAID can result in a decreased natriuretic response.
  • Concomitant use with:
    • Drugs affecting electrolyte balance (corticosteroids, amphotericin B, cardiac glycosides, other diuretics) requires careful monitoring.
    • Drugs that increase risk of renal injury or insufficiency should be avoided.
    • Aminoglycosides or cephalosporins may increase risk of nephrotoxicity and ototoxicity.
    • Other drugs metabolized by cytochrome P450 families may decrease their clearance, eg enalapril, buprenorphine, doxycycline, cyclosporine, isoflurane, sevoflurane, theophylline).
  • May increase risk of sulphonamide allergy.
  • Can reduce renal excretion of salicylates, leading to an increased risk of toxicity.
  • Antihypertensive drugs (especially ACE inhibitors) may be potentiated with co-administered with torasemide.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed Papers

  • Recent references from VetMedResource and PubMed.
  • ​Peddle G D, Singletary G E, Reynolds C A, Trafny D J, Machen M C, Oyama M A (2012) Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease.  J Vet Cardiol 1, 253-259 PubMed
  • Oyama M A, Peddle G D, Reynolds C A, Singletary G E (2011) Use of the loop diuretic torsemide in three dogs with advanced heart failure.  J Vet Cardiol 4, 287-292 PubMed
  • Uechi M, Matsuoka M, Kuwajima E, Kaneko T, Yamashita K, Fukushima U, Ishikawa Y (2003) The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and cats.  J Vet Med Sci 65 (10), 1057-1061 PubMed.

Other sources of information

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code