Canis ISSN: 2398-2942

Torasemide

Synonym(s): UpCard

Contributor(s): Gary Coxon

Introduction

Name

  • Torasemide.

Class of drug

  • Loop diuretic of the pyridyl sulfonylurea class.

Description

Chemical name

  • 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea.

Molecular formula

  • C16H20N4O3S

Molecular weight

  • 348.42

Physical properties

  • White to off-white tablets.

Storage requirements

  • No specific storage requirements.

Uses

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Indications

For dogs in acute crisis with pulmonary edema, pleural effusion and/or ascites requiring emergency treatment, use of injectable drugs should be considered first before commencing oral diuretic therapy.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Co-administration of loop diuretics and NSAIDs Analgesia NSAIDs can result in a decreased natriuretic response.
  • Concomitant use with:
    • Drugs affecting electrolyte balance (corticosteroids, amphotericin B, cardiac glycosides, other diuretics) requires careful monitoring.
    • Drugs that increase risk of renal injury or insufficiency should be avoided.
    • Aminoglycosides or cephalosporins may increase risk of nephrotoxicity and ototoxicity.
    • Other drugs metabolized by cytochrome P450 families may decrease their clearance, eg enalapril, buprenorphine, doxycycline, cyclosporine, isoflurane, sevoflurane, theophylline).
  • May increase risk of sulphonamide allergy.
  • Can reduce renal excretion of salicylates, leading to an increased risk of toxicity.
  • Antihypertensive drugs (especially ACE inhibitors) may be potentiated with co-administered with torasemide.

With diagnostic tests

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMed Resource and PubMed.
  • ​Peddle G D, Singletary G E, Reynolds C A, Trafny D J, Machen M C, Oyama M A (2012) Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease.  J Vet Cardiol 1, 253-259 PubMed
  • Oyama M A, Peddle G D, Reynolds C A, Singletary G E (2011) Use of the loop diuretic torsemide in three dogs with advanced heart failure.  J Vet Cardiol 4, 287-292 PubMed
  • Uechi M, Matsuoka M, Kuwajima E, Kaneko T, Yamashita K, Fukushima U, Ishikawa Y (2003) The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and cats.  J Vet Med Sci 65(10), 1057-1061 PubMed.

Other sources of information


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