Canis ISSN: 2398-2942

Tobramycin

Contributor(s): Vetstream Ltd

Introduction

Name

  • Tobramycin.

Class of drug

  • Aminoglycoside antibiotic.

Uses

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Indications

  • An aminoglycoside antibiotic which is used to treat gram-negative infections.
  • It is less active against most gram-negative organisms than gentamicin Gentamicin but appears to be more active againstPseudomonas aeroginosa Pseudomonas aeruginosa.
  • Aminoglycosides are ineffective at sites of low oxygen tension, eg abscesses.
  • All obligate anaerobes are resistant.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Nephrotoxic, ototoxic or neurotoxic agents, eg amphotericin B, cisplantin, furosemide, methoxyflurane

  • Avoid concurrent use.
  • Increase monitoring and adjust dosages when these drugs must be used together.
Beta-lactam antibiotics, eg penicillins, cephalosporins
  • Aminoglycosides may be inactivated when mixed in vitro.

Heparin

  • Aminoglycosides may be inactivated when mixed in vitro. This may also present a problemin vivoin patients who have substantially diminished renal function.

Non-depolarizing muscle relaxants, eg gallamine, metocurine, pancuronicum, suxamethonium, tubocurarine

  • Effect may be enhanced by aminoglycosides.

Penicillins or cephalosporins (Strep. faecalis), ticarcillin (Pseudomonas aeryginosa)

  • Synergism may occur.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA.

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