Canis ISSN: 2398-2942

Tobramycin

Introduction

Name

  • Tobramycin.

Class of drug

  • Aminoglycoside antibiotic.

Uses

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Indications

  • An aminoglycoside antibiotic which is used to treat gram-negative infections.
  • It is less active against most gram-negative organisms than gentamicin Gentamicin but appears to be more active againstPseudomonas aeroginosa Pseudomonas aeruginosa.
  • Aminoglycosides are ineffective at sites of low oxygen tension, eg abscesses.
  • All obligate anaerobes are resistant.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs



Nephrotoxic, ototoxic or neurotoxic agents, eg amphotericin B, cisplantin, furosemide, methoxyflurane
  • Avoid concurrent use.
  • Increase monitoring and adjust dosages when these drugs must be used together.
Beta-lactam antibiotics, eg penicillins, cephalosporins
  • Aminoglycosides may be inactivated when mixedin vitro.
Heparin
  • Aminoglycosides may be inactivated when mixedin vitro. This may also present a problemin vivoin patients who have substantially diminished renal function.
Non-depolarizing muscle relaxants, eg gallamine, metocurine, pancuronicum, suxamethonium, tubocurarine
  • Effect may be enhanced by aminoglycosides.
Penicillins or cephalosporins (Strep. faecalis), ticarcillin (Pseudomonas aeryginosa)
  • Synergism may occur.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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