ISSN 2398-2942      

Tiletamine with zolazepam

icanis
Contributor(s):

Jo Murrell

Vetstream Ltd


Introduction

Name

  • Tiletamine/zolazepam combination.

    Only available as 1:1 combinations - Telazol® (US) and Zoletial® (Europe).

Class of drug

  • Tiletamine - phencylidine derivative; dissociative anesthetic; NMDA-receptor antagonist.
  • Zolazepam - benzodiazepine; muscle relaxant; modulation of chloride ion transport following binding of the GABAA receptor.

Description

Chemical name

  • Tiletamine - 2-ethylamino-2-2(2-thienyl) cyclohexanone.
  • Zolazepam - 4-(2-fluorophenyl)-1,3,8-trimethyl-6,8-dihydrophyrazolo[3,4-e][1,4]diazepin-7(1H)-one.

Molecular formula

  • Tiletamine - C12H17NOS.
  • Zolazepam - C15H15FN4O.

Molecular weight

  • Tiletamine - 223.34 g.
  • Zolazepam - 286.304 g.

Physical properties

  • Yellow, crystalline freeze dried solid.
  • 571 mg active drug as a 1:1 ratio per vial.

Storage requirements

  • Store in a cool place below 30°C.
  • Once reconstituted can be kept at 4°C for 8 days with retention of 90% efficacy (Zoletil®).

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Not reported.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Spada E, Proverbio D, Bagnagatti De Giorgi G, Perego R, Valena E, Della Pepa A, Baggiani L (2015) Clinical and haematolgical responses of feline blood donors anaesthetised with a tiletamine and zolazepam combination. J Feline Med Surg 17 (4), 338-341 PubMed.
  • Jang M, Park S, Son W G, Jo S M, Hwang H, Seo K, Lee I (2014) Effect of tiletamine-zolazepam on the intraocular pressure of the dog. Vet Ophthalmol [Epub ahead of print] PubMed.
  • Mair A, Kloeppel H, Ticehurst K (2014) A comparison of low dose tiletamine-zolazepam or acepromazine combined with methadone for pre-anaesthetic medication in cats. Vet Anaesth Analg 41 (6), 630-635 PubMed.
  • Gomez-Villamandos R J, Martinez C, Navarrete R, Morgaz J, Dominguez J, Lopez I, Munoz P, Fernandez A, Granados M M (2013) Romifidine and low doses of tiletamine-zolazepam in dogs. Vet Anaesth Analg 40 (6), e40-47 PubMed.
  • Krimins R A, Ko J C, Weil A B, Payton M E (2012) Evaluation of anesthetic, analgesic, and cardiorespiratory effects in dogs after intramuscular administration of dexmedetomidine-butarphanol-tiletamine-zolazepam or dexmetedomidine-tramadol-ketamine drug combinations. Am J Vet Res 73 (11), 1707-1714 PubMed.
  • Krimins R A, Ko J C, Weil A B, Payton M E, Constable P D (2012) Hemodynamic effects in dogs after intramscular administration of a combination of dexmetomidine-butarphanol-tiletamine-zolazepam or dexmedetomidine-butarphanol-ketamine. Am J Vet Res 73 (9), 1363-1370 PubMed.
  • Ko J C, Abbo L A, Weil A B, Johnson B M, Payton M (2007) A comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butarphanol and tiletamine-zolazepam-butarphanol-medetomidine in cats. Vet Ther (3), 164-176 PubMed.
  • Cistola A M, Golder F J, Centonze L A, McKay L W & Levy J K (2004) Anesthetic and physiologic effects of tiletamine, zolazepam, ketamine, and xylazine combination (TKX) in feral cats undergoing surgical sterilization. J Feline Med Surg (5), 297-303 PubMed.
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